Eleutherinone, a novel fungitoxic naphthoquinone from Eleutherine bulbosa (Iridaceae)
Mem. Inst. Oswaldo Cruz
;
98(5): 709-712, July 2003. ilus, tab
Article
Dans Anglais
| LILACS
| ID: lil-344294
ABSTRACT
The dichloromethane extract prepared from the underground parts of Eleutherine bulbosa (Miller) Urban (Iridaceae) showed strong activity in the direct bioautography assay with the phytopathogenic fungus Cladosporium sphaerospermum. This assay was used to guide the fractionation of this extract and allowed the isolation of four compounds the new naphthoquinone eleutherinone[8-methoxy-1-methyl-1,3-dihydro-naphtho(2,3-c)furan-4,9 -dione] and the known compounds, previously isolated from this species, eleutherin [9-methoxy-1(R),3(S)-dimethyl-3,4-dihydro-1H-benzo(g)isochromene-5,10-dione], isoeleutherin [9-methoxy-1(R),3(R)-dimethyl-3,4-dihydro-1H-benzo(g)isochromene-5,10-dione], and eleutherol [4-hydroxy-5-methoxy-3(R)-methyl-3H-naphtho(2,3-c)furan-1 -one]. All quinonoid compounds showed strong antifungal activity in the bioautography assay at 100 æg/spot, while eleutherol was inactive
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Extraits de plantes
/
Naphtoquinones
/
Cladosporium
/
Antifongiques
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2003
Type:
Article
Pays d'affiliation:
Brésil
/
États-Unis d'Amérique
Institution/Pays d'affiliation:
Fiocruz/BR
/
Fundação Oswaldo Cruz/BR
/
University of California/US
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