Longitudinal comparison between plasma and seminal HIV-1 viral loads during antiretroviral treatment
Rev. Soc. Bras. Med. Trop
;
36(6): 689-694, nov.-dez. 2003. tab, graf
Article
Dans Anglais
| LILACS
| ID: lil-355345
ABSTRACT
This study was designed to investigate the impact of anti-retroviral therapy on both plasma and seminal HIV-1 viral loads and the correlation between viral loads in these compartments after treatment. Viral load, CD4+ and CD8+ T-cell counts were evaluated in paired plasma and semen samples from 36 antiretroviral therapy-naïve patients at baseline and on days 45, 90, and 180 of treatment. Slopes for blood and seminal viral loads in all treated patients were similar (p = 0.21). Median HIV-1 RNA titers in plasma and semen at baseline were 4.95 log10 and 4.48 log10 copies/ml, respectively. After 180 days of therapy, the median viral load declined to 3.15 log10 copies/ml (plasma) and 3.2 log10 copies/ml (semen). At this timepoint 22 patients presented HIV-1 viral load below 400 copies/ml in either plasma or semen, but only 9 had viral loads below 400 copies/ml in both compartments.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Sperme
/
Infections à VIH
/
VIH-1 (Virus de l'Immunodéficience Humaine de type 1)
/
Rapport CD4-CD8
/
Agents antiVIH
/
Charge virale
Type d'étude:
Étude observationnelle
Limites du sujet:
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Rev. Soc. Bras. Med. Trop
Thème du journal:
Médecine tropicale
Année:
2003
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Santa Casa de Misericórdia de Vitória/BR
/
Universidade Federal do Espírito Santo/BR
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