Behavior of cholinesterase and liver mitochondrial function in dogs submitted to normothermic ischemia and reperfusion
Acta cir. bras
;
18(supl.5): 38-41, 2003. graf
Article
Dans Anglais
| LILACS
| ID: lil-358583
ABSTRACT
Purpose:
The plasmatic activity of the cholinesterase (CHE) and the Tiver mitochondrial function, expressed by the ratio of respiratory control (RCR), were studied during normothermic ischemia.Methods:
Sixteen adult mongrels, eight females and eight males were submitted to ischemia by clamping of the hepatic artery, portal vein and infrahepatic inferior vena cava, infra-hepatic, for two h, follwed by reperfusion for 1 h. The CHE and the mitochondrial function were evaluated at 60 and 120 min. of ischemia and at 15 and 60 minutes of reperfusion.Results:
The CHE decreased, significandy, during ischemia and in reperfusion. The RCR was decreased at 120 min. of ischemia, returning to the initial values on reperfusion.Conclusion:
In this study, the CHE was a sensitive indicator of ischemic injury , suggesting irreversibility of ischemia injury. The RCR, by other side, showed a greater sensibility than the CHE in detection sense, during the studied period, the reversibility of the hepatic ischemic injury.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Mitochondries du foie
/
Reperfusion
/
Cholinesterases
/
Ischémie
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Acta cir. bras
Thème du journal:
Chirurgie générale
/
Procedimentos Cir£rgicos Operat¢rios
Année:
2003
Type:
Article
/
descriptif de projet
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade de São Paulo/BR
/
Universidade do Distrito Federal/BR
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