Capacidad ácidosupresora del omeprazol 20 mg comprimidos versus pantoprazol 20 y 40 mg comprimidos en voluntarios / Acid-supressing capacity of omeprazole 20 mg tablets vs pantoprazole 20 and 40 mg tablets. A pilot study in volunteers
Acta gastroenterol. latinoam
;
33(4): 199-203, 2003. tab
Article
Dans Espagnol
| LILACS
| ID: lil-359984
RESUMO
OBJECTIVE:
To compare the acid-supressing capacity of omeprazole (OZ) 20 mg tablets vs pantoprazole (PZ) 20 and 40 mg tablets, in healthy volunteers, with 24-h intragastric pH-metry. MATERIAL ANDMETHODS:
Open, randomized, cross-over trial in 10 healthy volunteers; on days 0.8 and 22, 24-h intragastric pH-metry. Day 0, basal, thereafter 7 days with OZ or PZ 20 mg/day; day 8, pH-metry, then "wash out" for 7 days and thereafter 7 more days' therapy with PZ or OZ. On day 22 a 24-h intragastric pH control was performed again. In the last treatment stage, all of them were administered pantoprazole 40 mg/day for 8 days again with a 24-h pH recording at the end.RESULTS:
24-h pH-metry expressed as the time (hours) in which the pH was < or = 4 and the values as mean +/- standard deviation. BASAL 22.12 +/- 1.54, POST-OZ 9.78 +/- 6.72, POST-PZ 20 15.65 +/- 5.65, POST-PZ 40 8.57 +/- 5.93. Statistical evaluation with two way repeated measures ANOVA p < 0.0001. Newman Keuls post-hoc test (1) vs (2) p < 0.003; (1) vs (3) p < 0.03; (2) vs (4) 0.65.CONCLUSIONS:
According to the results it might be stated that both proton pump inhibitors have acid-supressing capacity and omeprazole in equal dosis is more effective than pantoprazole as acid-supressor, with statistically significative differences. There was no difference between 20 mg omeprazole and 40 mg pantoprazole.
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Indice:
LILAS (Amériques)
Sujet Principal:
Sulfoxydes
/
Benzimidazoles
/
Oméprazole
/
Pompes à protons
/
Antienzymes
/
Acide gastrique
Type d'étude:
Essai clinique contrôlé
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Espagnol
Texte intégral:
Acta gastroenterol. latinoam
Thème du journal:
Gastroentérologie
Année:
2003
Type:
Article
Pays d'affiliation:
Argentine
Institution/Pays d'affiliation:
Hospital de Gastroenterologia Dr. C. Bonorino Udaondo/AR
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