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Uric acid as a monitor of oxidative stress in a random skin flap in rats
Freire, Sueli Teresinha; Ferreira, Lydia Masako; Gomes, Heitor Carvalho; Percario, Sandro.
  • Freire, Sueli Teresinha; Universidade Federal de São Paulo. Escola Paulista de Medicina. BR
  • Ferreira, Lydia Masako; Universidade Federal de São Paulo. Escola Paulista de Medicina. BR
  • Gomes, Heitor Carvalho; Universidade Federal de São Paulo. Escola Paulista de Medicina. BR
  • Percario, Sandro; Universidade Federal de São Paulo. Escola Paulista de Medicina. BR
Acta cir. bras ; 18(6): 534-536, nov.-dez. 2003. tab
Article Dans Anglais | LILACS | ID: lil-360212
RESUMO

Purpose:

To verify the possible role of uric acid as a monitor of oxidative stress in a random skin flap, in the rat.

Methods:

This study utilized 21 adult male Wistar-EPM rats divided, at random, in three groups of seven animals, to evaluate the behavior of uric acid levels during oxidative stress zero, 5 and 15 minutes after elevation of the flap. According toS the time schedule, skin samples were collected in order to allow determination of uric acid and malondialdehyde (MDA) levels.

Results:

Uric acid levels in the skin samples did not change with time, but the values in normal skin were higher since the beginning. Malondialdehyde (MDA) levels in the skin samples remained stable throughout.

Conclusion:

Uric acid levels in the flap skin were lower than those in the normal skin, denoting local oxidative stress.
Sujets)
Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Lambeaux chirurgicaux / Acide urique / Stress oxydatif / Malonaldéhyde Limites du sujet: Animaux langue: Anglais Texte intégral: Acta cir. bras Thème du journal: Chirurgie générale / Procedimentos Cir£rgicos Operat¢rios Année: 2003 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade Federal de São Paulo/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Lambeaux chirurgicaux / Acide urique / Stress oxydatif / Malonaldéhyde Limites du sujet: Animaux langue: Anglais Texte intégral: Acta cir. bras Thème du journal: Chirurgie générale / Procedimentos Cir£rgicos Operat¢rios Année: 2003 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade Federal de São Paulo/BR