Contenido de ADN y sobrevida en el carcinoma subseroso de la vesícula biliar / DNA content and survival in subserous gallbladder carcinoma
Rev. méd. Chile
;
132(7): 794-800, jul. 2004. tab, graf
Article
Dans Espagnol
| LILACS
| ID: lil-366578
ABSTRACT
Background:
The clinical and morphological characterization of the subserous gallbladder carcinomas is controversial.Aim:
To study the prognostic importance of DNA content of subserous gallbladder carcinoma. Material andmethods:
We studied 104 females aged 60±12 years old and 16 men aged 70±13 years old. In all of them diagnosis was established after mapping of cholecystectomy sample and had a complete clinical follow up. DNA content was measured by flow cytometry.Results:
All tumors were adenocarcinoma, and only 16 percent were well differentiated. Aneuploidy was observed in 29 cases (26 perceeeent) with DNA index fluctuating between 1.1 and 1.8. Lymphatic vessel tumor involvement was present in 16 of 22 cases with aneuploidy and in 22 of 46 diploid tumors (p= 0.05). Eighty nine percent of aneuploid tumors were detected macroscopically and 11 percent were unapparent. Five years survival was non significantly better among patients with diploid tumors than in patients with aneuploid tumors (45 and 28 percent, respectively, p= 0.2). The histological differentiation was the only variable significantly associated with survival.Conclusions:
Aneuploidy is present in 26 percent of subserous gallbladder carcinoma. It is not related with any of the morphological or clinical variables studied in this series of patients.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
ADN tumoral
/
Tumeurs de la vésicule biliaire
Type d'étude:
Étude pronostique
Limites du sujet:
Femelle
/
Humains
/
Mâle
Pays comme sujet:
Amérique du Sud
/
Chili
langue:
Espagnol
Texte intégral:
Rev. méd. Chile
Thème du journal:
Médicament
Année:
2004
Type:
Article
/
descriptif de projet
Pays d'affiliation:
Chili
Institution/Pays d'affiliation:
Universidad de Chile/CL
/
Universidad de la Frontera/CL
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