Hepatitis C virus genotypes in blood donors from the Federal District, Central Brazil
Mem. Inst. Oswaldo Cruz
;
99(8): 895-897, dez. 2004. tab
Article
Dans Anglais
| LILACS
| ID: lil-393775
ABSTRACT
The objective of this study was to characterize hepatitis C virus (HCV) genotypes in blood donors from the Federal District, Central Brazil, and to compare HCV screening by serological assays and reverse transcriptase polymerase chain reaction (RT-PCR). Plasma samples from 57 individuals with reactive or indeterminate results in serological anti-HCV screening assays (ELISA or EIA) were tested for HCV RNA by RT-PCR. The results from a confirmatory LIA serological assay were also evaluated. The 5' non-coding region of the HCV genome was amplified from 41 PCR positive samples (71.9 percent), which were further characterized by nucleotide sequencing analysis. Of these, 60.9 percent were of HCV genotype 1 and 39.1 percent of genotype 3.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Donneurs de sang
/
Hépatite C
/
Hepacivirus
/
Anticorps de l'hépatite C
Limites du sujet:
Adolescent
/
Adulte
/
Femelle
/
Humains
/
Mâle
Pays comme sujet:
Amérique du Sud
/
Brésil
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2004
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Agência Nacional de Vigilância Sanitária/BR
/
Hemocentro de Brasília/BR
/
Universidade Federal de Góias/BR
/
Universidade de Brasília/BR
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