Biodistribution studies of bee venom and spider toxin using radiotracers
J. venom. anim. toxins incl. trop. dis
;
11(1): 39-50, jan.-abr. 2005. tab, graf
Article
Dans Anglais
| LILACS, SES-SP, VETINDEX
| ID: lil-396699
RESUMO
The use of radiotracers allows the understanding of the bioavailability process, biodistribution, and kinetics of any molecule labelled with an isotope, which does not alter the molecule's biological properties. In this work, technetium-99m and iodine-125 were chosen as radiotracers for biodistribution studies in mice using bee (Apis mellifera) venom and a toxin (PnTX2-6) from the Brazilian "armed" spider (Phoneutria nigriventer) venom. Incorporated radioactivity was measured in the blood, brain, heart, lung, liver, kidney, adrenal gland, spleen, stomach, testicle, intestine, muscle, and thyroid gland. Results provided the blood kinetic parameter, and different organs distribution rates.(AU)
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Venins d'araignée
/
Venins d'abeille
/
Abeilles
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
J. venom. anim. toxins incl. trop. dis
Année:
2005
Type:
Article
Institution/Pays d'affiliation:
Instituto Butantan/BR
/
Instituto de Pesquisas Energéticas e Nucleares/BR
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