Nitric oxide synthase activity and endogenous inhibitors in rats recovered from allergic encephalomyelitis
Mem. Inst. Oswaldo Cruz
;
100(supl.1): 25-27, Mar. 2005. ilus, tab
Article
Dans Anglais
| LILACS
| ID: lil-402172
ABSTRACT
We have previously reported that in comparison with normal rats, the presence of experimental allergic encephalomyelitis (EAE) leads to decreased endogenous inhibitory activity (EIA) of Ca2+-dependent nitric oxide synthase (NOS) in both brain and serum, and increased expression of protein 3-nitrotyrosine (NT) in brain. In this work we show that animals recovered from the clinical signs of EAE are not different from controls in terms of either brain NOS activity, EIA of NOS, or NT expression. These results suggest that parallel to the reversal of the disease symptoms, a normalization of the production of nitric oxide and related species occurs.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Encéphale
/
Encéphalomyélite auto-immune expérimentale
/
Nitric oxide synthase type III
/
Monoxyde d'azote
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2005
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade de São Paulo/BR
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