CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi-elicited myocarditis
Mem. Inst. Oswaldo Cruz
;
100(supl.1): 93-96, Mar. 2005.
Article
Dans Anglais
| LILACS
| ID: lil-402181
RESUMO
The comprehension of the pathogenesis of Trypanosoma cruzi-elicited myocarditis is crucial to delineate new therapeutic strategies aiming to ameliorate the inflammation that leads to heart dysfunction, without hampering parasite control. The augmented expression of CCL5/RANTES and CCL3/MIP-1alpha, and their receptor CCR5, in the heart of T. cruzi-infected mice suggests a role for CC-chemokines and their receptors in the pathogenesis of T. cruzi-elicited myocarditis. Herein, we discuss our recent results using a CC-chemokine receptor inhibitor (Met-RANTES), showing the participation of CC-chemokines in T. cruzi infection and unraveling CC-chemokine receptors as an attractive therapeutic target for further evaluation in Chagas disease.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Trypanosoma cruzi
/
Cardiomyopathie associée à la maladie de Chagas
/
Récepteurs aux chimiokines
/
Chimiokines CC
/
Myocardite
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2005
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Instituto Oswaldo Cruz/BR
/
Universidade Federal de Minas Gerais/BR
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