Thymus involution in alloxan diabetes: analysis of mast cells
Mem. Inst. Oswaldo Cruz
; 100(supl.1): 127-130, Mar. 2005. ilus, graf
Article
de En
| LILACS
| ID: lil-402188
Bibliothèque responsable:
BR1.1
RESUMO
We previously reported that alloxan-induced diabetes results in reduction in the number and reactivity of mast cells at different body sites. In this study, the influence of diabetes on thymic mast cells was investigated. Thymuses from diabetic rats showed marked alterations including shrinkage, thymocyte depletion, and increase in the extracellular matrix network, as compared to those profiles seen in normal animals. Nevertheless, we noted that the number and reactivity of mast cells remained unchanged. These findings indicate that although diabetes leads to critical alterations in the thymus, the local mast cell population is refractory to its effect. This suggests that thymic mast cells are under a different regulation as compared to those located in other tissues.
Texte intégral:
1
Indice:
LILACS
Sujet Principal:
Thymus (glande)
/
Diabète expérimental
/
Mastocytes
Limites du sujet:
Animals
langue:
En
Texte intégral:
Mem Inst Oswaldo Cruz
/
Mem. Inst. Oswaldo Cruz
/
Mem. Inst. Oswaldo Cruz (Online)
/
Memórias do Instituto Oswaldo Cruz (Impresso)
/
Proceedings of the Instituto Oswaldo Cruz
Thème du journal:
MEDICINA TROPICAL
/
PARASITOLOGIA
Année:
2005
Type:
Article