Epithelial cell signaling responses to enterohemorrhagic Escherichia coli infection
Mem. Inst. Oswaldo Cruz
;
100(supl.1): 199-203, Mar. 2005. ilus
Article
Dans Anglais
| LILACS
| ID: lil-402200
RESUMO
Enterohemorrhagic Escherichia coli, including the serotype O157H7 that is most commonly identified with human disease, cause both sporadic cases and outbreaks of non-bloody diarrhea and hemorrhagic colitis. In about 10 percent of infected subjects, the hemolytic uremic syndrome (hemolytic anemic, thrombocytopenia, and acute renal failure) develops, likely as a consequence of systemic spread of bacterial-derived toxins variously referred to as Shiga-like toxin, Shiga toxin, and Verotoxin. Increasing evidence points to a complex interplay between bacterial products - for example, adhesins and toxins - and host signal transduction pathways in mediating responses to infection. Identification of critical signaling pathways could result in the development of novel strategies for intervention to both prevent and treat this microbial infection in humans.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Transduction du signal
/
Cellules épithéliales
/
Infections à Escherichia coli
/
Hémorragie gastro-intestinale
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
/
Humains
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2005
Type:
Article
Pays d'affiliation:
Canada
Institution/Pays d'affiliation:
Hospital for Sick Children/CA
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS