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Long-term ethanol intoxication reduces inflammatory responses in rats
Carvalho, E. M; Brito, G. A. C; Pessoa, B. B. G. P; Ribeiro, R. A; Capaz, F. R.
  • Carvalho, E. M; Universidade Federal do Ceará. Departamento de Fisiologia e Farmacologia. Fortaleza. BR
  • Brito, G. A. C; Universidade Federal do Ceará. Departamento de Morfologia. Fortaleza. BR
  • Pessoa, B. B. G. P; Universidade Federal do Ceará. Departamento de Fisiologia e Farmacologia. Fortaleza. BR
  • Ribeiro, R. A; Universidade Federal do Ceará. Departamento de Fisiologia e Farmacologia. Fortaleza. BR
  • Capaz, F. R; Universidade Federal do Ceará. Departamento de Fisiologia e Farmacologia. Fortaleza. BR
Braz. j. med. biol. res ; 38(1): 81-89, Jan. 2005. graf
Article Dans Anglais | LILACS | ID: lil-405535
ABSTRACT
The anti-inflammatory effects of long-term ethanol intoxication were determined during ethanol treatment and withdrawal on the basis of neutrophil and eosinophil migration, hind paw edema and mast cell degranulation. Male Wistar rats (180-200 g, around 2 months of age) were exposed to increasing concentrations of ethanol vapor over a 10-day period. One group was evaluated immediately after exposure (treated group - intoxicated), and another was studied 7 h later (withdrawal group). Ethanol inhalation treatment significantly inhibited carrageenan- (62 percent for the intoxicated group, N = 5, and 35 percent for the withdrawal group, N = 6) and dextran-induced paw edema (32 percent for intoxicated rats and 26 percent for withdrawal rats, N = 5 per group). Ethanol inhalation significantly reduced carrageenan-induced neutrophil migration (95 percent for intoxicated rats and 41 percent for withdrawn rats, N = 6 per group) into a subcutaneous 6-day-old air pouch, and Sephadex-induced eosinophil migration to the rat peritoneal cavity (100 percent for intoxicated rats and 64 percent for withdrawn rats, N = 6 per group). A significant decrease of mast cell degranulation was also demonstrated (control, 82 percent; intoxicated, 49 percent; withdrawn, 51 percent, N = 6, 6 and 8, respectively). Total leukocyte and neutrophil counts in venous blood increased significantly during the 10 days of ethanol inhalation (leukocytes, 13, 27 and 40 percent; neutrophils, 42, 238 and 252 percent, respectively, on days 5, 9 and 10, N = 7, 6 and 6). The cell counts decreased during withdrawal, but were still significantly elevated (leukocytes, 10 percent; neutrophils, 246 percent, N = 6). These findings indicate that both the cellular and vascular components of the inflammatory response are compromised by long-term ethanol intoxication and remain reduced during the withdrawal period.
Sujets)
Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Dégranulation cellulaire / Éthanol / Intoxication alcoolique / Oedème / Inflammation / Mastocytes Type d'étude: Étude pronostique Limites du sujet: Animaux langue: Anglais Texte intégral: Braz. j. med. biol. res Thème du journal: Biologie / Médicament Année: 2005 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade Federal do Ceará/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Dégranulation cellulaire / Éthanol / Intoxication alcoolique / Oedème / Inflammation / Mastocytes Type d'étude: Étude pronostique Limites du sujet: Animaux langue: Anglais Texte intégral: Braz. j. med. biol. res Thème du journal: Biologie / Médicament Année: 2005 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade Federal do Ceará/BR