Evaluation of the nitrergic myenteric neurons in the distal colon of diabetic rats treated with acetyl-L-Carnitine
Braz. j. morphol. sci
;
21(2): 105-110, Apr.-Jun. 2004. ilus, tab
Article
Dans Anglais
| LILACS
| ID: lil-406363
ABSTRACT
In this work, we evaluated the effect of acetyl-L-carnitine supplmentation on the presence of NADPH-diaphorase positive myenteric neurons in the distal colon of rats with diabetes mellitus induced by streptozotocin. Rats 105 days old were divided into four groups normoglycemic, normoglycemic supplemented with acetyl-L-carnitine, diabetic and diabetic supplemented with acetyl-L-carnitine. Diabetes was induced by the administration of streptozotocin (35 mg/kg, i. v.). Supplementation with acetyl-L-carnitine was done for 105 days. The neuronal density was similar in all groups. In diabetic rats, the area of neuronal cell body profile was greater (p<0, 05) than in normoglycemic rats, whereas in diabetic rats receiving acetyl-L-carnitine the areas were smaller than in the non-supplemented diabetic rats (p<0, 05). The increase in the colonic area of diabetic rats was greater than in diabetic rats treated with acetyl-L-carnitine (p<0, 05), indicating that the increment in the population of these neurons was higher in treated diabetic rats. These results suggest that the beneficial effect of carnitine is restricted to preventing an excessive increase in neuronal area. The greater dilatation of the distal colon seen in diabetic rats supplemented with acetyl-L-carnitine probably represents and adverse effect of this compound.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Acétyl-carnitine
/
Diabète
/
NADPH dehydrogenase
/
Neurones
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Braz. j. morphol. sci
Thème du journal:
Anatomie
Année:
2004
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Estadual Oeste do Paraná/BR
/
Universidade Estadual Paulista/BR
/
Universidade Estadual de Maringá/BR
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