Effects of aggrecan on schwann cell migration in vitro and nerve regeneration in vivo
Braz. j. morphol. sci
;
21(3): 125-130, Jul.-Sept. 2004. ilus, mapas, tab, graf
Article
Dans Anglais
| LILACS
| ID: lil-406366
ABSTRACT
Although the role of many small proteoglycans in regeneration of the nervous system has been established, little is known about the involvement of large proteoglycans. In this study, we evaluated the effects of aggrecan, a high molecular mass proteoglycan, on Schwann cells in vitro and investigated its effects on axonal regeneration after sciatic nerve tubulization. The number of regenerated axons and their morphometrical parameters were determined in vivo. Aggrecan increased the number and viability of Schwann cells in vitro. Similarly, the number of regenerated fibers increased significantly when aggrecan was applied in vivo, but there were no alterations in the morphometrical parameters. These results indicate that aggrecan contributes to the regeneration of peripheral axons and has a positive effect on the Schwann cells.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Protéoglycanes
/
Cellules de Schwann
/
Techniques in vitro
/
Cellules
/
Techniques de culture cellulaire
/
Matrice extracellulaire
/
Glycosaminoglycanes
/
Régénération nerveuse
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Braz. j. morphol. sci
Thème du journal:
Anatomie
Année:
2004
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade de Campinas/BR
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