La biodiversidad humana y sus efectos sobre la variabilidad farmacologica: enzimas CYP2D6 y NAT2 en poblaciones amerindias de Panama, Colombia y Costa Rica / Human biodiversity and its effects on the pharmacological variability: CYP2D6 and NAT2 enzymes in Amerind populations of Panama, Colombia and Costa Rica
Rev. méd. Panamá
;
20(3): 98-107, Sept. 1995.
Article
Dans Espagnol
| LILACS
| ID: lil-409933
ABSTRACT
Human biodiversity originates partially from human microevolution, which have produced different populations. This biodiversity is responsible for most of the variability in drug response. We present the methodology employed in population pharmacology studies and general information about the CYP2D6 and NAT2 systems. We report results obtained in Embera and Ngawbe Amerindians, who are characterized by a low phenotypic and genotypic CYP2D6 diversity. In regard to NAT2, Amerindians are distinguished by a high allelic frequency of S3 and low ones of S1 and S2, situation which is reversed in Caucasians
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Indice:
LILAS (Amériques)
Sujet Principal:
Pharmacogénétique
/
Acetyltransferases
/
Variation génétique
/
Indien Amérique Centrale
/
Indien Amérique Sud
/
Mixed function oxygenases
Limites du sujet:
Humains
Pays comme sujet:
Amérique centrale
/
Amérique du Sud
/
Colombie
/
Costa Rica
/
Panama
langue:
Espagnol
Texte intégral:
Rev. méd. Panamá
Thème du journal:
Médicament
Année:
1995
Type:
Article
Pays d'affiliation:
Panama
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