Sativa seeds against Schistosoma mansoni different stages
Mem. Inst. Oswaldo Cruz
;
100(2): 205-211, Apr. 2005. tab, graf
Article
Dans Anglais
| LILACS
| ID: lil-410861
RESUMO
The schistosomicidal properties of Nigella sativaseeds were tested in vitro against Schistosoma mansoni miracidia, cercariae, and adult worms. Results indicate its strong biocidal effects against all stages of the parasite and also showed an inhibitory effect on egg-laying of adult female worms. In the present work we also studied the effects of crushed seeds on some antioxidant enzymes; which have a role in protection of adult worms against host oxidant killing; as well as some enzymes of glucose metabolism; which have a crucial role in the survival of adult worms inside their hosts. The data revealed that the used drug induce an oxidative stress against adult worms which indicated by a decrease in the activities of both antioxidant enzymes, superoxide dismutase, glutathione peroxidase, and glutathione reductase and enzymes of glucose metabolism, hexokinase and glucose-6-phosphate dehydrogenase. Disturbing of such enzymes of adult worms using N. sativa seeds could in turn render the parasite vulnerable to damage by the host and may play a role in the antischistosomal potency of the used drug.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Oxidoreductases
/
Schistosoma mansoni
/
Schistosomicides
/
Graines
/
Nigella
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2005
Type:
Article
Pays d'affiliation:
Égypte
Institution/Pays d'affiliation:
National Research Centre/EG
/
Theodor Bilharz Research Institute/EG
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