Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans
Mem. Inst. Oswaldo Cruz
;
100(3): 325-330, May 2005. ilus, tab
Article
Dans Anglais
| LILACS
| ID: lil-411033
ABSTRACT
Genotoxic effects of benznidazole were studied by the induction of homozygosis of genes previously present in heterozygous. UT448//A757 diploid strain was used in the benznidazole's recombinagenesis test. Although toxic effects on growth of colonies were not observed, 75 and 100 æM benznidazole induced an increasing of mitotic recombination events in diploid strain. Results were related to the induction of chromosomal breaks by the antiparasitic drug.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Aspergillus nidulans
/
Diploïdie
/
Mutagènes
/
Nitroimidazoles
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2005
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Estadual de Maringá/BR
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