Harderian gland of wistar rats revised as a protoporphyrin ix producer
Braz. j. morphol. sci
;
22(1): 43-51, jan.-mar. 2005. ilus, graf
Article
Dans Anglais
| LILACS
| ID: lil-413785
RESUMO
In 1694 Johann Jacob Harder described, for the first time, the harderian gland, located near the eye in the great majority of vertebrates, and regarded it as a lacrimal gland. This gland has multiple functions that vary according to the animal species. In the present work, we review the literature on the harderian gland of rats, focusing our study on the detection of great amounts of protoporphyrin IX (PpIX) produced by rodent glands. Protoporphyrin IX is a powerful photosensitizer that is widely used for photodynamic therapy (PDT). We also discuss the anatomic and the histological evidence for the presence of PpIX in the harderian gland of Wistar rats. Protoporphyrin IX has been detected in the lumen and in acinar cells of this gland, as confirmed by fluorescence microscopy. These findings together with numerous reports in the literature suggest that the harderian gland could be useful experimental model for studying the photodynamic process.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Protoporphyrines
/
Glande de Harder
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Braz. j. morphol. sci
Thème du journal:
Anatomie
Année:
2005
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
State University of Campinas/BR
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