Cirrosis biliar primaria: experiencia de trece años en dos centros de referencia / Primary biliary cirrhosis: a thirteen years experience
Rev. méd. Chile
;
134(4): 469-474, abr. 2006. tab
Article
Dans Espagnol
| LILACS
| ID: lil-428547
RESUMO
Background:
Primary biliary cirrhosis (PBC) is a chronic cholestatic disease, which can progress to hepatic failure.Aim:
To study the clinical presentation, pathological features, treatment and outcome of a group of patients with PBC. Material andmethods:
Retrospective review of medical records of 115 patients (110 females, age range 30-76 years) with PBC. Clinical presentation, pathological stage, treatment, outcome and eventual use of liver transplantation, were recorded.Result:
Seventy eight percent of patients were symptomatic at presentation (itching in 69% and malaise in 62%). Antimitochondrial antibodies were positive in 56%. No clinical or laboratory differences were observed between symptomatic patients or those with positive antimitochondrial antibodies and the rest of the study group. Sjögren syndrome was present in 38%, hypothyroidism in 13%, scleroderma in 7% and rheumatoid arthritis in 5%. Initially, 61% had fibrosis and/or cirrhosis, and ursodeoxycholic acid was indicated in 94% of the patients. Fifteen patients underwent liver transplantation due to upper digestive bleeding or itching. Survival has been 67% at 36 months after transplantation. In one transplanted liver, PBC recurred.Conclusions:
An early diagnosis and treatment of a progressive disease such as PBC will reduce the incidence of complications and the use of costly treatments.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Cirrhose biliaire
Type d'étude:
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
/
Étude de dépistage
Limites du sujet:
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Espagnol
Texte intégral:
Rev. méd. Chile
Thème du journal:
Médicament
Année:
2006
Type:
Article
Pays d'affiliation:
Chili
Institution/Pays d'affiliation:
Clínica Las Condes/CL
/
Universidad de Chile/CL
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