Mitochondrial apoptotic pathways
Biocell
;
29(2): 149-161, ago. 2005. ilus
Article
Dans Anglais
| LILACS
| ID: lil-429669
RESUMO
Apoptosis or programmed cell death (PCD) is a physiological process characteristic of pluricellular organisms leading to self-destruction of the cell. It is therefore involved in development, homeostasis and host defense. However, a significant difference has been shown between mammalian cell apoptosis and non-mammalian cell apoptosis mitochondria are implicated only in the former. Execution of PCD includes the release of several proapoptotic proteins from the intermembrane space of mitochondria. They could exert their actions through a caspase dependent as well as a caspase independent way. On the other hand, regulation of PCD is mainly given by the Bcl-2 family members, which are in turn essentially regulated by activation of death receptors and/or DNA damage. Nowadays, execution of apoptosis is better known than its regulation. Nevertheless, we are still far of a complete understanding of the apoptotic process
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Indice:
LILAS (Amériques)
Sujet Principal:
Apoptose
/
Cytochromes c
/
Conduit auditif externe
/
Homéostasie
/
Mitochondries
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Biocell
Thème du journal:
Clulas
Année:
2005
Type:
Article
Pays d'affiliation:
Argentine
Institution/Pays d'affiliation:
University of Buenos Aires/AR
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