Hepatitis B virus infection profile in hemodialysis patients in Central Brazil: prevalence, risk factors, and genotypes
Mem. Inst. Oswaldo Cruz
;
101(6): 689-692, Sept. 2006. graf, tab
Article
Dans Anglais
| LILACS
| ID: lil-437066
ABSTRACT
Hemodialysis patients are at high risk for hepatitis B virus (HBV) infection. A survey was conducted in the hemodialysis population of the state of Goiás, Central Brazil, aiming to assess the prevalence of HBV infection, to analyse associated risk factors, and also to investigate HBV genotypes distribution. A total of 1095 patients were interviewed in 15 dialysis units. Serum samples were screened for HBV serological markers by enzyme-linked immunosorbent assay. Hepatitis B surface antigen (HBsAg) positive samples were tested for HBV DNA by polymerase chain reaction and genotyped by restriction fragment length polymorphism. Global HBV infection prevalence was 29.8 percent (95 percent CI 27.1-32.5). Multivariate analysis of risk factors showed that male gender, length of time on hemodialysis, and blood transfusion before 1993 were associated with HBV positivity. HBV DNA was detected in 65.4 percent (17/26) of the HBsAg-positive samples. Thirteen of 17 HBV DNA positive samples were genotyped. Genotype D (61.5 percent) was predominant, followed by A (30.8 percent), while genotype F was detected in only one (7.7 percent) sample.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Virus de l'hépatite B
/
Dialyse rénale
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Hépatite B
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Anticorps de l'hépatite B
/
Antigènes de surface du virus de l'hépatite B
Type d'étude:
Etude diagnostique
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Etude d'étiologie
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Étude de prévalence
/
Facteurs de risque
Limites du sujet:
Adolescent
/
Adulte
/
Adulte très âgé
/
Aged80
/
Enfant
/
Enfant d'âge préscolaire
/
Femelle
/
Humains
/
Mâle
Pays comme sujet:
Amérique du Sud
/
Brésil
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2006
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Fundação Oswaldo Cruz/BR
/
Instituto de Patologia Tropical e Saúde Pública/BR
/
Universidade Federal de Goiás/BR
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