Expresión inmunohistoquímica del complejo E-caderina-catenina en cáncer gástrico: Relación con variables clínico-morfológicas y sobrevida de pacientes / Immunohistochemical expression of the E-cadherin-catenin complex in gastric cancer
Rev. méd. Chile
;
134(8): 1002-1009, ago. 2006. ilus, tab
Article
Dans Espagnol , Anglais
| LILACS
| ID: lil-438371
ABSTRACT
Background:
The E-cadherin/catenin complex plays an essential role in the control of epithelial differentiation. Abnormal expression in tumors correlates with histological grade, advanced stage and poor prognosis.Aim:
To evaluate the expression pattern of E-cadherin/catenin complex in gastric carcinoma and analyze their association with tumor clinicopathological features and patient survival. Material andMethods:
Inmunohistochemical staining of E-cadherin, alpha and ß-catenin was performed from paraffin specimens of 65 gastric carcinomas.Results:
Abnormal expression of E-cadherin, alpha and ß-catenin was demonstrated in 82 percent, 85 percent and 88 percent of gastric carcinomas, respectively. There was a significant correlation between abnormal expression and Lauren pathological classification and depth of infiltration, but not with tumor stage, positive lymph node metastases and survival.Conclusion:
Abnormal expression of E-cadherin, alpha and ß-catenin occurs frequently in gastric carcinoma and correlates with histological grade.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Tumeurs de l'estomac
/
Cadhérines
/
Bêta-Caténine
/
Alpha-Caténine
/
Protéines tumorales
Type d'étude:
Étude pronostique
Limites du sujet:
Femelle
/
Humains
/
Mâle
Pays comme sujet:
Amérique du Sud
/
Chili
langue:
Anglais
/
Espagnol
Texte intégral:
Rev. méd. Chile
Thème du journal:
Médicament
Année:
2006
Type:
Article
/
descriptif de projet
Pays d'affiliation:
Chili
Institution/Pays d'affiliation:
Universidad de La Frontera/CL
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