Osteonecrosis asociada al uso de bifosfonatos: A propósito de un caso clínico / Osteonecrosis associated with the use of biphosphonates: Case report
Rev. méd. Chile
;
134(9): 1161-1165, sept. 2006. ilus
Article
Dans Espagnol , Anglais
| LILACS
| ID: lil-438419
ABSTRACT
Biphosphonates reduce the risk of skeletal events and are currently part of standards of therapy in myeloma. Recently, zoledronate and pamidronate have been linked to osteonecrosis of the jaw, specially after surgical dental procedures. We report a 84 year-old man with multiple myeloma who developed spontaneous osteonecrosis of both jaws, after 36 months of therapy with zoledronate with a cumulative dose of 136 mg. We discuss the pathogenic mechanisms, and review the recommendations on prevention and management of this new complication for neoplastic patients under prolonged therapy with biphosphonates.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Ostéonécrose
/
Maladies de la mâchoire
/
Diphosphonates
/
Agents de maintien de la densité osseuse
/
Imidazoles
/
Myélome multiple
Type d'étude:
Guide de pratique
/
Facteurs de risque
Limites du sujet:
Adulte très âgé
/
Aged80
/
Humains
/
Mâle
langue:
Anglais
/
Espagnol
Texte intégral:
Rev. méd. Chile
Thème du journal:
Médicament
Année:
2006
Type:
Article
Pays d'affiliation:
Chili
Institution/Pays d'affiliation:
Clínica Alemana de Santiago/CL
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