Factores y mecanismos involucrados en la transmissión y el desarollo de la infección congénita por Trypanosoma cruzi / Factors and mechanisms involved in the transmission and development of congenital infection with Trypanosoma cruzi
Rev. Soc. Bras. Med. Trop
;
38(supl.2): 105-107, 2005.
Article
Dans Espagnol
| LILACS
| ID: lil-444164
ABSTRACT
This paper synthesizes the results obtained from multidisciplinary studies of Bolivian cases of congenital infection with T. cruzi. Congenital infection and congenital Chagas disease do not result from transmission of a particular strain of parasite, but from an equilibrium between complex phenomena, such as a weak maternal type 1 adaptative immune response associated with high maternal parasitemia, an invasion of placental chorion and umbilical cord by parasites, in front of a fetal T. cruzi-specific immune response characterized by an activation of cytotoxic CD8 T cells producing IFN-gamma and able to limit parasite multiplication and morbi-mortality of congenital Chagas disease.
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Indice:
LILAS (Amériques)
Sujet Principal:
Trypanosoma cruzi
/
Maladie de Chagas
/
Complications parasitaires de la grossesse
/
Transmission verticale de maladie infectieuse
Limites du sujet:
Animaux
/
Femelle
/
Humains
/
Grossesse
langue:
Espagnol
Texte intégral:
Rev. Soc. Bras. Med. Trop
Thème du journal:
Médecine tropicale
Année:
2005
Type:
Article
/
Congrès et conférence
Pays d'affiliation:
Belgique
Institution/Pays d'affiliation:
Université Livre de Bruxelles/BE
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