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Paracoccidioides brasiliensis translation and protein fate machineries revealed by functional genome analysis
Souza, D. P; Silva, S. S; Baptista, A. J; Nicola, A. M; Kyaw, C. M; Silva-Pereira, I.
  • Souza, D. P; Universidade de Brasília. Departamento de Biologia Celular. Instituto de Biologia. Brasília. BR
  • Silva, S. S; Universidade de Brasília. Departamento de Biologia Celular. Instituto de Biologia. Brasília. BR
  • Baptista, A. J; Universidade de Brasília. Departamento de Biologia Celular. Instituto de Biologia. Brasília. BR
  • Nicola, A. M; Universidade de Brasília. Departamento de Biologia Celular. Instituto de Biologia. Brasília. BR
  • Kyaw, C. M; Universidade de Brasília. Departamento de Biologia Celular. Instituto de Biologia. Brasília. BR
  • Silva-Pereira, I; Universidade de Brasília. Departamento de Biologia Celular. Instituto de Biologia. Brasília. BR
Genet. mol. res. (Online) ; 4(2): 273-289, 30 jun. 2005. tab
Article Dans Anglais | LILACS | ID: lil-445287
ABSTRACT
The translational and post-translational modification machineries of Paracoccidioides brasiliensis were assessed by means of comparative analyses of PbAESTs (P. brasiliensis assembled expressed sequence tags) with sequences deposited on different databases. Of the 79 sequences corresponding to cytosolic ribosomal proteins, we were able to find 78 in the P. brasiliensis transcriptome. Nineteen of the 27 Saccharomyces cerevisiae genes related to translation initiation were also found. All eukaryotic elongation factors were detected in P. brasiliensis transcriptome, with eEF1A as one of the most expressed genes. Translation termination is performed, in eukaryotes, by factors 1 and 3 (eRF1, eRF3). In P. brasiliensis transcriptome it was possible to identify eRF3, but not eRF1. Sixteen PbAESTs showing aminoacyl-tRNA synthetase-predicted activities were found in our analyses, but no cysteinyl-, leucyl-, asparagyl- and arginyl-tRNA synthetases were detected. Among the mitochondrial ribosomal proteins, we have found 20 and 18 orthologs to S. cerevisiae large and small ribosomal subunit proteins, respectively. We have also found three PbAESTs similar to Neurospora crassa mitochondrial ribosomal genes, with no similarity with S. cerevisiae genes. Although orthologs to S. cerevisiae mitochondrial EF-Tu, EF-G and RF1 have been found in P. brasiliensis transcriptome, no sequences corresponding to functional EF-Ts were detected. In addition, 64 and 28 PbAESTs associated to protein modification and degradation, respectively, were found. These results suggest that these machineries are well conserved in P. brasiliensis, when compared to other organisms.
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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Paracoccidioides / Protéines ribosomiques / Génome fongique / Modification traductionnelle des protéines Type d'étude: Étude pronostique Pays comme sujet: Amérique du Sud / Brésil langue: Anglais Texte intégral: Genet. mol. res. (Online) Thème du journal: Biologie moléculaire / Génétique Année: 2005 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade de Brasília/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Paracoccidioides / Protéines ribosomiques / Génome fongique / Modification traductionnelle des protéines Type d'étude: Étude pronostique Pays comme sujet: Amérique du Sud / Brésil langue: Anglais Texte intégral: Genet. mol. res. (Online) Thème du journal: Biologie moléculaire / Génétique Année: 2005 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade de Brasília/BR