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Event-related potentials (P300) and neuropsychological assessment in boys exhibiting Duchenne muscular dystrophy
Della Coletta, Marcus Vinicius; Scola, Rosana Herminia; Wiemes, Gislaine Richter Minhoto; Fonseca, Cláudia Nasser; Mãder, Maria Joana; Freund, Aline Andrade; Werneck, Lineu César.
Affiliation
  • Della Coletta, Marcus Vinicius; Universidade Federal do Paraná. Hospital de Clínicas. Internal Medicine Department. Neuromuscular/Neurology Division. Curitiba. BR
  • Scola, Rosana Herminia; Universidade Federal do Paraná. Hospital de Clínicas. Internal Medicine Department. Neuromuscular/Neurology Division. Curitiba. BR
  • Wiemes, Gislaine Richter Minhoto; UFPR. Hospital de Clínicas. Surgery Department. Otorrinolaringology Service. Curitiba. BR
  • Fonseca, Cláudia Nasser; UFPR. Hospital de Clínicas. Psychology Service. Curitiba. BR
  • Mãder, Maria Joana; UFPR. Hospital de Clínicas. Psychology Service. Curitiba. BR
  • Freund, Aline Andrade; UFPR. Hospital de Clínicas. Neuromuscular and Genetic Laboratory. Curitiba. BR
  • Werneck, Lineu César; Universidade Federal do Paraná. Hospital de Clínicas. Internal Medicine Department. Neuromuscular/Neurology Division. Curitiba. BR
Arq. neuropsiquiatr ; Arq. neuropsiquiatr;65(1): 59-62, mar. 2007. graf, tab
Article de En | LILACS | ID: lil-446681
Bibliothèque responsable: BR1.1
ABSTRACT

OBJECTIVE:

To examine auditory cognitive evoked potentials (P300 potentials) and neuropsychological dysfunction in patients with Duchenne muscular dystrophy (DMD).

METHOD:

P300 potentials and neuropsychological test results were obtained from 16 healthy control boys and 20 DMD patients. Full Intelligence Quotients (IQ) were estimated for patients and control group. Mean age was 9.5 years in the DMD patient group, and 10 years in the control group (p>0.05).

RESULTS:

The mean IQ values were 64.35 in the DMD patients and 82.68 in the control group (p=0.01). Mean P300 values were 347.6 in the DMD group and 337.4 in the control group (p=0.14). There was no significant correlation between parameters in each group.

CONCLUSION:

DMD patients showed a poor performance as evaluated by P300 potential compared to the control group, although the difference was not statistically significant. Systematic alterations in neuropsychological test results were found, the differences paralleling those detected in IQ.
RESUMO

OBJETIVO:

Avaliar potenciais evocados cognitivos auditivos (P300) e disfunções neuropsicológicas em pacientes com distrofia muscular de Duchenne (DMD).

MÉTODO:

Potenciais auditivos P300 e testes neuropsicológicos foram obtidos de 16 controles e 20 pacientes com DMD. Valores de quociente de inteligência (QI) foram estimados para os dois grupos. A media de idade foi de 9.5 anos no grupo DMD e 10 anos no grupo controle (p>0.05).

RESULTADOS:

Os valores médios de QI foram 64.35 no grupo DMD e 82.68 no grupo controle (p=0.01). A média de valores de P300 foi 347.6 no grupo DMD e 337.4 no grupo controle (p=0.14). Não houve correlação significativa entre os parâmetros em cada grupo.

CONCLUSÃO:

Os pacientes com DMD mostraram um pior desempenho nas testagens de P300 quando comparados com o grupo controle, embora a diferença não tenha apresentado diferença significativa. Alterações sistemáticas foram encontradas nos testes neuropsicológicos, correspondendo às alterações significativas vistas nos valores de QI.
Sujet(s)
Texte intégral: 1 Indice: LILACS Sujet Principal: Troubles de la cognition / Myopathie de Duchenne / Potentiels évoqués auditifs Type d'étude: Observational_studies / Risk_factors_studies Limites du sujet: Adolescent / Child / Humans / Male langue: En Texte intégral: Arq. neuropsiquiatr Thème du journal: NEUROLOGIA / PSIQUIATRIA Année: 2007 Type: Article
Texte intégral: 1 Indice: LILACS Sujet Principal: Troubles de la cognition / Myopathie de Duchenne / Potentiels évoqués auditifs Type d'étude: Observational_studies / Risk_factors_studies Limites du sujet: Adolescent / Child / Humans / Male langue: En Texte intégral: Arq. neuropsiquiatr Thème du journal: NEUROLOGIA / PSIQUIATRIA Année: 2007 Type: Article