Enhancement of the antimalarial efficacy of amodiaquine by chlorpheniramine in vivo
Mem. Inst. Oswaldo Cruz
;
102(3): 417-420, June 2007. tab
Article
Dans Anglais
| LILACS
| ID: lil-452507
ABSTRACT
Resistance in Plasmodium falciparum to amodiaquine (AQ) can be reversed in vitro with with antihistaminic and tricyclic antidepressant compounds, but its significance in vivo is unclear. The present report presents the enhancement of the antimalarial efficacy of AQ by chlorpheniramine, an H1 receptor antagonist that reverses chloroquine (CQ) resistance in vitro and enhances its efficacy in vivo, in five children who failed CQ and/or AQ treatment, and who were subsequently retreated and cured with a combination of AQ plus CP, despite the fact that parasites infecting the children harboured mutant pfcrtT76 and pfmdr1Y86 alleles associated with AQ resistance. This suggests a potential clinical appliation of the reversal phenomenon.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Protéines de transport membranaire
/
Protéines de protozoaire
/
Chloroquine
/
Chlorphénamine
/
Paludisme à Plasmodium falciparum
/
Amodiaquine
/
Antihistaminiques des récepteurs H1
/
Antipaludiques
Limites du sujet:
Animaux
/
Humains
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2007
Type:
Article
Pays d'affiliation:
Nigeria
Institution/Pays d'affiliation:
University of Ibadan/NG
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