Multiorgan involvement due to cytomegalovirus infection in AIDS
Braz. j. infect. dis
;
11(1): 176-178, Feb. 2007. ilus, tab
Article
Dans Anglais
| LILACS
| ID: lil-454701
ABSTRACT
Cytomegalovirus (CMV) infection is a relatively late complication of AIDS. Like other viruses contributing to co-morbidity of HIV infection, cytomegalovirus has the propensity to cause multiorgan involvement. We report the case of a 34-year-old seropositive man who presented with bilateral lower limb weakness and symptomatic pallor. He was already on antiretroviral drugs for a month prior to presentation. Detailed clinical examination and laboratory investigations revealed cytomegalovirus polyradiculoneuropathy associated with bone marrow dysplasia. Dysplasia of haematopoeitic cell lines occurs in 30 percent to 70 percent of HIV infected patients, and is often indistinguishable from myelodysplastic syndrome. However, in our case, the bone marrow picture reverted back to normal with treatment of the CMV infection, pointing to a possible role of CMV as the causative agent of bone marrow dysplasia. Moreover, CMV has been incriminated as a pathogen producing the immune reconstitution inflammatory syndrome. The onset of the disease in our case one month after initiation of HAART strongly raises the possibility of this being a case of CMV related IRIS. This is the first reported case where IRIS has presented with CMV polyradiculoneuropathy and bone marrow dysplasia. We would like to highlight that in today's era of HIV care, clinicians should be aware of the possibility of multiorgan involvement by CMV, for appropriate management of this disease in the background of AIDS.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Polyradiculoneuropathie
/
Syndromes myélodysplasiques
/
Infections opportunistes liées au SIDA
/
Infections à cytomégalovirus
Type d'étude:
Etude diagnostique
Limites du sujet:
Adulte
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Braz. j. infect. dis
Thème du journal:
Maladies transmissibles
Année:
2007
Type:
Article
Pays d'affiliation:
Inde
Institution/Pays d'affiliation:
Bankura Sammilani Medical College/IN
/
Medical College/IN
/
Midnapore Medical College/IN
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