Short-interfering RNAs as antivirals against rabies
Braz. j. infect. dis
;
11(2): 224-225, Apr. 2007.
Article
Dans Anglais
| LILACS
| ID: lil-454723
ABSTRACT
This study aimed to test in vitro a RNA-interference based antiviral approach for rabies with short-interfering RNAs (siRNAs) against rabies virus nucleoprotein mRNA. BHK-21 cells were infected with serial dilutions of PV rabies virus strain and transfected with a pool of three siRNAs. Direct immunofluorescence staining showed a 5-time decrease in virus titer when compared to a non-treated plate, showing a promising new approach to the development of antivirals for rabies treatment.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Virus de la rage
/
Réplication virale
/
Petit ARN interférent
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Braz. j. infect. dis
Thème du journal:
Maladies transmissibles
Année:
2007
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Pasteur Institute/BR
/
University of São Paulo/BR
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