Association of cytokine genetic polymorphism with hepatites B infection evolution in adult patients
Mem. Inst. Oswaldo Cruz
; 102(4): 435-440, June 2007. tab
Article
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| LILACS
| ID: lil-454793
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BR1.1
ABSTRACT
The infection by the hepatitis B virus (HBV) has different forms of evolution, ranging from self-limited infection to chronic hepatic disease. The objective of this study was to evaluate the influence of cytokine genetic polymorphisms in the disease evolution. The patients were divided into two groups, one with chronic HBV (n = 30), and the other with self-limited infection (n = 41). The genotyping for TNF (-308), TGFB1 (+869, +915), IL-10 (1082, -819, and -592), IL-6 (-174), and IFNG (+874) was accomplished by the PCR-SSP (polymerase chain reaction with sequence specific primers technique using the One Lambda kit. Although no statistically significant differences were found between the groups, the combination of TNF -308GG and IFNG +874TA was found in a lower frequency in chronic patients than in individuals with self-limited infection (26.7 versus 46.3 percent; P = 0.079; OR = 0.40; IC95 percent = 0.14-1.11). In chronic patients with histological alterations it was not observed the genotype TGFB1+869 C/C, against 24.4 percent in the self limited infection group (100 versus 75.6 percent; P = 0.096; OR = 7.67; IC95 percent = 0.42-141.63). Further studies in other populations, and evaluation of a greater number of individuals could contribute for a better understanding of the cytokine genetic polymorphism influence in HBV infection evolution.
Mots clés
Texte intégral:
1
Indice:
LILACS
Sujet Principal:
Polymorphisme génétique
/
Cytokines
/
Amorces ADN
/
Hépatite B chronique
Type d'étude:
Observational_studies
/
Risk_factors_studies
Limites du sujet:
Adult
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Female
/
Humans
/
Male
langue:
En
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
MEDICINA TROPICAL
/
PARASITOLOGIA
Année:
2007
Type:
Article