Geobacillus stearothermophilus LV cadA gene mediates resistance to cadmium, lead and zinc in zntA mutants of Salmonella entérica serovar Typhimurium
Biol. Res
;
39(4): 661-668, 2006. ilus
Article
Dans Anglais
| LILACS
| ID: lil-456601
ABSTRACT
Salmonella entérica serovar Typhimurium cells expressing the cadA gene of Geobacillus stearothermophilus LV exhibit a hypersensitive phenotype to cadmium chloride. Deletion of the ORF STM3576 from the Salmonella genome resulted in cadmium, lead and zinc sensitivity, confirming that this ORF is a homologue of the zntA gene. The observed sensitivity was reverted upon expression of the G. stearothermophilus LV cadA gene. These results indicate that the cadA gene product is involved in Cd, Pb and Zn resistance as a classical P-type ATPase and strongly suggest that the observed hypersensitive phenotype to these metals can be related to the function of the host ·zntA gene product.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Salmonella typhimurium
/
Geobacillus stearothermophilus
/
Adenosine triphosphatases
langue:
Anglais
Texte intégral:
Biol. Res
Thème du journal:
Biologie
Année:
2006
Type:
Article
/
descriptif de projet
Pays d'affiliation:
Chili
/
États-Unis d'Amérique
Institution/Pays d'affiliation:
Chiron Corporation/US
/
Universidad de Santiago de Chile/CL
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