Bioactivity of two Turkish endemic Centaurea species, and their major constituents
Rev. bras. farmacogn
;
17(2): 155-159, abr.-jun. 2007. tab, ilus
Article
Dans Anglais
| LILACS
| ID: lil-456982
ABSTRACT
The antioxidant activity, general toxicity and cytotoxicity of the methanol extracts of Centaurea urvillei subs. armata and C. mucronifera have been assessed, respectively, by the DPPH assay, the brine shrimp lethality and the MTT cytotoxicity assays. The reversed-phase HPLC analysis of the methanol extracts afforded two bioactive dibenzylbutyrolactone-type lignans, matairesinoside (1) and arctiin (2). The structures of these lignans were elucidated by comprehensive spectroscopic analyses as well as by the direct comparison of experimental data with respective literature data.
RESUMO
A atividade antioxidante, a toxicidade geral e a citotoxidade dos extratos metanólicos de Centaurea urvillei subs. armata e C. mucronifera foram analisados, respectivamente, pelo ensaio DPPH e pelos ensaios de letalidade de Artemia salina e de citotoxidade MTT. A análise dos extratos metanólicos em CLAE de fase reversa apresentou duas lignanas biotivas do tipo dibenzilbutirolactona, matairesinosídeo (1) e arctiina (2). As estruturas destas lignanas foram elucidadas através de análises espectroscópicas completas bem como por comparação direta dos dados experimentais com os respectivos dados da literatura.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Artemia
/
Extraits de plantes
/
Lignanes
/
Asteraceae
/
Centaurea
langue:
Anglais
Texte intégral:
Rev. bras. farmacogn
Thème du journal:
Pharmacie
Année:
2007
Type:
Article
Pays d'affiliation:
Bangladesh
/
Turquie
/
Royaume-Uni
Institution/Pays d'affiliation:
Canakkale Onsekiz Mart University/TR
/
The Robert Gordon University/GB
/
University of Aberdeen/GB
/
University of Dhaka/BD
/
University of Ulster/GB
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