Toll-like Receptors are Key Participants in Innate Immune Responses
Biol. Res
;
40(2): 97-112, 2007. ilus
Article
Dans Anglais
| LILACS
| ID: lil-468181
ABSTRACT
During an infection, one of the principal challenges for the host is to detect the pathogen and activate a rapid defensive response. The Toll-like family of receptors (TLRs), among other pattern recognition receptors (PRR), performs this detection process in vertebrate and invertebrate organisms. These type I transmembrane receptors identify microbial conserved structures or pathogen-associated molecular patterns (PAMPs). Recognition of microbial components by TLRs initiates signaling transduction pathways that induce gene expression. These gene products regulate innate immune responses and further develop an antigen-specific acquired immunity. TLR signaling pathways are regulated by intracellular adaptor molecules, such as MyD88, TIRAP/Mal, between others that provide specificity of individual TLR- mediated signaling pathways. TLR-mediated activation of innate immunity is involved not only in host defense against pathogens but also in immune disorders. The involvement of TLR-mediated pathways in auto-immune and inflammatory diseases is described in this review article.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Récepteurs de type Toll
/
Immunité innée
/
Infections
/
Inflammation
Limites du sujet:
Animaux
/
Humains
langue:
Anglais
Texte intégral:
Biol. Res
Thème du journal:
Biologie
Année:
2007
Type:
Article
Pays d'affiliation:
Chili
Institution/Pays d'affiliation:
Universidad de Chile/CL
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