E-cadherin/beta-catenin expression pattern, clinicopathological parameters and prognosis in gastric carcinomas
Appl. cancer res
;
26(3): 94-104, July-Sept. 2006.
Article
Dans Anglais
| LILACS, Inca
| ID: lil-478274
ABSTRACT
Objectives:
This study aimed to evaluate the expression pattern of some markers (E-cadherin and â-catenin) related to cellular adhesion and their relationship with histological tumor type according to Lauréns system, clinicopathological features and patient survival. Material andMethods:
We did immunohistochemical analysis in a retrospective series of 446 gastric carcinomas using tissue microarray method (TMA). Clinicopathological features and overall survival data of all patients were retrospectively reviewed from hospital records. For all statistical analyses, p<0.05 was considered significant.Results:
The reduced/absent expression of E-cadherin occurred more frequently in diffuse than intestinal type tumors and it was correlated with worse biological behavior and poor prognosis for patients with diffuse type gastric carcinomas. The pattern of â-catenin expression was closely related to histological type and E-cadherin expression. Although patients with nuclear/absent â-catenin immunoreactivity showed worse survival index, no statistical correlation was found with overall survival. In multivariated analysis, only pTNM staging system persisted as independent prognostic marker.Conclusion:
In the present study, alterations in E-cadherin/â-catenin complex expression showed significant correlations with clinicopathological parameters, as well as its implications for tumor progression and prognosis in gastric cancer. Our results indicate that markers expression pattern may be a useful marker of differentiation and suggest further investigations of their prognostic relevance to specific histological groups.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Normes de référence
/
Tumeurs de l'estomac
/
Bêta-Caténine
Type d'étude:
Étude pronostique
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Appl. cancer res
Thème du journal:
Tumeurs
Année:
2006
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Hospital A. C. Camargo/BR
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