Histopathological evaluation in experimental envenomation of dogs with Crotalus durissus terrificus venom
J. venom. anim. toxins incl. trop. dis
;
14(1): 82-99, 2008. ilus, graf
Article
Dans Anglais
| LILACS
| ID: lil-479341
ABSTRACT
The present work evaluated histopathological aspects in experimental envenomation of dogs with Crotalus durissus terrificus venom. Twenty-eight mixed breed adult dogs were divided into three groups of seven animals each Group I - only venom; Group II - venom + 50ml antiophidic serum + fluid therapy; Group III - venom + 50ml antiophidic serum + fluid therapy + urine alkalization. Lyophilized venom of Crotalus durissus terrificus was reconstituted in saline solution and inoculated subcutaneously at the dose of 1mg/kg body weight. Three animals of each group were subjected to euthanasia, and their muscular tissue, brain, spleen, kidneys, heart, lungs, stomach, small and large intestines, and popliteal lymph node fragments were collected for histopathological evaluation. There was myonecrosis in the inoculated limb, renal tubular degeneration, lymphoid hyperplasia of spleen, and unspecific reactive hepatitis. These results show the antigenicity and action of the venom on the immune system.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Venins de crotalidé
/
Chiens
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
J. venom. anim. toxins incl. trop. dis
Thème du journal:
Toxicologie
Année:
2008
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Maringá University Center/BR
/
São Paulo State University/BR
/
University of Western São Paulo/BR
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