Estado actual del diagnóstico y presentaciones clínicas de enfermedad celíaca: Estudio multicéntrico / Diagnosis and clinical presentations of celiac disease: A multicenter study
Rev. méd. Chile
;
136(3): 296-303, mar. 2008. graf, tab
Article
Dans Espagnol
| LILACS
| ID: lil-484898
ABSTRACT
Background:
Ample use of serological markers of high sensitivity and specificity led to relevant changes in the epidemiology of celiac disease. The impact of these changes in our country is poorly known.Aim:
To assess the diagnostic procedures, clinical presentations and follow up of celiac disease as conducted in current pediatric practice. Material andmethods:
A multicentric retrospective study of patients diagnosed between 2000 and 2005 in five pediatric hospitals in Santiago, Chile. Data was obtained from clinical records, recorded in electronic spreadsheets and analyzed by descriptive statistics.Results:
Seventy four of 83 identified patients fulfilled the inclusion criteria and were analyzed. Mean time to reach the diagnosis was 2.1 years. Cases younger than 10 years presented digestive manifestations such as chronic diarrhea and abdominal distension. Twenty one percent of older patients had atypical presentations (mainly short stature, refractory anaemia). Ten percent of cases were screened because a first degree relative had celiac disease. All patients had significant duodenal/jejunal lesion. IgA-antiendomysial antibodies (n =65) and IgA-antigliadin antibodies (n =23) were the most commonly used screening tests used but often, they were not available for follow up. A second biopsy was planned in all patients but only 26 had it due to repeated dietary transgressions, often due to unnoticed consumption of gluten in poorly labeled products.Conclusions:
Digestive manifestations were the main presentation form for celiac disease among patients under 10 years of age. Atypical symptoms become relevant in patients older than 10 years. Antiendomysial and antitransglutaminase antibody measurement should be incorporated for routine screening and follow up of celiac disease in public hospitals. To improve food labeling about their gluten content is needed.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Maladie coeliaque
/
Régime sans gluten
Type d'étude:
Etude diagnostique
/
Étude observationnelle
/
Étude pronostique
Limites du sujet:
Adolescent
/
Enfant
/
Enfant d'âge préscolaire
/
Femelle
/
Humains
/
Mâle
langue:
Espagnol
Texte intégral:
Rev. méd. Chile
Thème du journal:
Médicament
Année:
2008
Type:
Article
Pays d'affiliation:
Chili
Institution/Pays d'affiliation:
Hospital Exequiel González Cortés/CL
/
Hospital Luis Calvo Mackenna/CL
/
Hospital Roberto del Río/CL
/
Hospital San Borja Arriarán/CL
/
Hospital San Juan de Dios/CL
/
Universidad de Chile/CL
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