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Population and mutation analysis of Y-STR loci in a sample from the city of São Paulo (Brazil)
Soares-Vieira, José A; Billerbeck, Ana E. C; Iwamura, Edna S. M; Mendonca, Berenice B; Gusmão, Leonor; Otto, Paulo A.
  • Soares-Vieira, José A; Universidade de São Paulo. Faculdade de Medicina. Departamento de Medicina Legal. São Paulo. BR
  • Billerbeck, Ana E. C; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Laboratório de Hormônios e Genética Molecular. São Paulo. BR
  • Iwamura, Edna S. M; Universidade de São Paulo. Faculdade de Medicina. Departamento de Medicina Legal. São Paulo. BR
  • Mendonca, Berenice B; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Laboratório de Hormônios e Genética Molecular. São Paulo. BR
  • Gusmão, Leonor; Universidade do Porto. Instituto de Patologia e Imunologia Molecular. Porto. PT
  • Otto, Paulo A; Universidade de São Paulo. Instituto de Biociências. Departamento de Genética e Biologia Evolutiva. São Paulo. BR
Genet. mol. biol ; 31(3): 651-656, 2008. tab
Article Dans Anglais | LILACS | ID: lil-490051
ABSTRACT
The haplotypes of seven Y-chromosome STR loci (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, and DYS393) were determined in a sample of 634 healthy Brazilian males (190 adult individuals and 222 father-son pairs). The 412 adults were unrelated, and the 222 father-son pairs had their biological relationship confirmed using autosomal STRs (LR > 10,000). Among the 412 adults, a total of 264 different 7-loci haplotypes were identified, 210 of which were unique. The most frequent haplotype was detected in 31 instances, occurring with a frequency of 7.52 percent. The haplotype diversity index was calculated as 98.83 percent. Upon transmission of the 1,554 alleles, in 222 father-son pairs, six mutations were observed, with an average overall rate of 3.86 x 10-3 per locus. A haplotype with a duplicated DYS389I locus, and another with duplicated DYS389I, DYS389II, and DYS439 loci were detected in both fathers and their respective sons.

Texte intégral: Disponible Indice: LILAS (Amériques) Pays comme sujet: Amérique du Sud / Brésil langue: Anglais Texte intégral: Genet. mol. biol Thème du journal: Génétique Année: 2008 Type: Article Pays d'affiliation: Brésil / Portugal Institution/Pays d'affiliation: Universidade de São Paulo/BR / Universidade do Porto/PT

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Texte intégral: Disponible Indice: LILAS (Amériques) Pays comme sujet: Amérique du Sud / Brésil langue: Anglais Texte intégral: Genet. mol. biol Thème du journal: Génétique Année: 2008 Type: Article Pays d'affiliation: Brésil / Portugal Institution/Pays d'affiliation: Universidade de São Paulo/BR / Universidade do Porto/PT