Effects of the ascorbic acid supplementation on NADH-diaphorase myenteric neurons in the duodenum of diabetic rats
Biocell
; 30(2): 295-300, ago. 2006. ilus, tab, graf
Article
de En
| LILACS
| ID: lil-491554
Bibliothèque responsable:
AR40.1
ABSTRACT
We assessed the ascorbic acid (AA) supplementation on the myenteric neurons in the duodenum of rats. Fifteen rats with 90 days of age were divided into three groups control (C), diabetics (D) and ascorbic acid treated diabetics (DA). After 120 days of daily treatment with AA, the duodenum was submitted to the NADH-diaphorase (NADH-d) histochemical technique, which allowed us to evaluate theneuronal density in an area of 8.96 mm2 for each duodenum, and also to measure the cellular profile area of 500 neurons per group. The supplementation promoted an increase on AA levels. The neuronal density (p < 0.05) was higher in the group DA when compared to group D. There were no significant differences in the neuronal areas, when we compared groups C (204 +/- 16.5) and D (146.3 +/- 35.84) to groups D and DA (184.5 +/- 5.6 ) (p > 0.05). The AA-supplementation avoided the density reduction of the NADHd myenteric neurons in the duodenum of diabetic rats.
Texte intégral:
1
Indice:
LILACS
Sujet Principal:
Acide ascorbique
/
Rat Wistar
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Diabète expérimental
/
Duodénum
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Dihydrolipoamide dehydrogenase
/
Neurones
Limites du sujet:
Animals
langue:
En
Texte intégral:
Biocell
Thème du journal:
Clulas
Année:
2006
Type:
Article