Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate
Mem. Inst. Oswaldo Cruz
;
103(5): 437-442, Aug. 2008. ilus, tab
Article
Dans Anglais
| LILACS
| ID: lil-491964
ABSTRACT
The synthetic n-alkyl esters of gallic acid (GA), also known as gallates, especially propyl, octyl and dodecyl gallates, are widely employed as antioxidants by food and pharmaceutical industries. The inhibitory effects of GA and 15 gallates on Herpes Simplex Virus type 1 (HSV-1) and Human Immunodeficiency Virus (HIV-1) replication were investigated here. After a preliminary screening of these compounds, GA and pentyl gallate (PG) seemed to be the most active compounds against HSV-1 replication and their mode of action was characterized through a set of assays, which attempted to localize the step of the viral multiplication cycle where impairment occurred. The detected anti-HSV-1 activity was mediated by the inhibition of virus attachment to and penetration into cells, and by virucidal properties. Furthermore, an anti-HIV-1 activity was also found, to different degrees. In summary, our results suggest that both compounds could be regarded as promising candidates for the development of topical anti-HSV-1 agents, and further studies concerning the anti-HIV-1 activity of this group of molecules are merited.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Antiviraux
/
VIH-1 (Virus de l'Immunodéficience Humaine de type 1)
/
Herpèsvirus humain de type 1
/
Acide gallique
Limites du sujet:
Animaux
/
Humains
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2008
Type:
Article
/
descriptif de projet
Pays d'affiliation:
Brésil
/
Suède
Institution/Pays d'affiliation:
Fiocruz/BR
/
Universidade Federal Fluminense/BR
/
Universidade Federal de Santa Catarina/BR
/
Universidade de Göteborg/SE
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