Polymorphism in the Plasmodium vivax msp 3: gene in field samples from Tierralta, Colombia
Mem. Inst. Oswaldo Cruz
;
103(5): 493-496, Aug. 2008. ilus, tab
Article
Dans Anglais
| LILACS
| ID: lil-491980
ABSTRACT
We evaluated the Plasmodium vivax polymorphism by studying the Pvmsp-3 gene's polymorphic region by PCR-RFLP in 55 samples from patients living in Tierralta, Colombia. Three different sizes of the Pvmsp-3 gene were found, type A (1,900 bp), type B (1,500 bp) and type C (1,100 bp); most of the samples were type A (96.4 percent). The Pvmsp-3 gene exhibited high polymorphism. Seven restriction patterns were found when using Alu I, and nine were found with Hha I; 12 different alleles were obtained when these patterns were combined. The findings suggest that this gene could be used in Colombia as a molecular epidemiologic marker for genotyping P. vivax.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Plasmodium vivax
/
Polymorphisme génétique
/
ADN des protozoaires
Limites du sujet:
Animaux
/
Humains
Pays comme sujet:
Amérique du Sud
/
Colombie
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2008
Type:
Article
/
descriptif de projet
Pays d'affiliation:
Colombie
Institution/Pays d'affiliation:
Instituto Nacional de Salud/CO
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