Pharmacological characterization of venoms obtained from Mexican toxoglossate gastropods on isolated guinea pig ileum
J. venom. anim. toxins incl. trop. dis
;
14(3): 497-513, 2008. graf, tab
Article
Dans Anglais
| LILACS
| ID: lil-492212
ABSTRACT
The protein-containing extracts prepared from the venom ducts of Conus austini, Conus spurius and Polystira albida caused a concentration-dependent inhibition of spontaneous contractions in guinea pig ileum. The most potent extract was obtained from P. albida venom ducts (IC50 equal 0.11 more or less 0.02 microg protein/mL). The three extracts produced a moderate inhibition of contractions elicited by acetylcholine (ACh 1 microM), suggesting the presence of anticholinergic compounds. The contractile response elicited by nicotine (10 microM) was significantly reduced by the extracts prepared from the ducts of C. austini and P. albida, which indicates that the venom produced by these species contains toxins that target neuronal nicotinic receptors. All three extracts significantly inhibited contractions evoked by histamine (0.5 miM), particularly those from C. spurius and P. albida. These findings reveal the presence of antihistaminergic compounds not previously described in any conoidean venom. Finally, we found that only the extract prepared from C. spurius ducts decreased KCl (60 mM)-induced contractions, indicating that the venom of this snail contains compounds that block voltage-dependent Ca2 more or Na more channels.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Cochons d'Inde
/
Iléum
/
Venins de mollusque
Limites du sujet:
Animaux
Pays comme sujet:
Mexico
langue:
Anglais
Texte intégral:
J. venom. anim. toxins incl. trop. dis
Thème du journal:
Toxicologie
Année:
2008
Type:
Article
Pays d'affiliation:
Mexique
Institution/Pays d'affiliation:
Autonomus University of Querétaro/MX
/
National Autonomous University of Mexico/MX
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