Tratamento de vasculopatia livedóide com imunoglobulina intravenosa / Treatment of Livedoid Vasculopathy with intravenous immunoglobulin

RESUMO

A vasculopatia livedóide apresenta-se com dor e úlceras de cicatrização lenta em membros inferiores, e fisiopatologia obscura. As estratégias terapêuticas incluem cicatrizantes, antiinflamatórios e imunossupressores, sem relatos de benefício permanente. Administrou-se imunoglobulina em paciente refratário a outras terapias e avaliou-se o comprometimento da pele antes e depois por meio de escore clínico. Houve regressão significativa das lesões. A droga foi bem tolerada, e a terapia foi finalizada.

ABSTRACT

Livedoid vasculopathy presents with pain and slowly healing ulcerations of the lower limbs, and has obscure pathophysiology. Usual therapeutics include rheologic, anti-inflammatory and immunosuppressing agents with no reports of permanent benefits. Immunoglobulin was administered to a patient who was refractory to other treatments and skin involvement was assessed by means of clinical score before and after treatment. There was a significant healing of the lesions. Imunoglobulim was well tolerated and therapy was discontinued.