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Efecto del probiótico Saccharomyces boulardii en la prevención de la diarrea asociada con antibióticos en adultos ambulatorios en tratamiento con amoxicilina / Effect of probiotic Saccharomyces boulardii on prevention of antibiotic-associated diarrhea in adult outpatients with amoxicillin treatment
Bravo, María Verónica; Bunout, Daniel; Leiva, Laura; de la Maza, María Pía; Barrera, Gladys; de la Maza, Javier; Hirsch, Sandra.
  • Bravo, María Verónica; Universidad de Chile. Instituto de Nutrición y Tecnología de los Alimentos. Santiago. CL
  • Bunout, Daniel; Universidad de Chile. Instituto de Nutrición y Tecnología de los Alimentos. Santiago. CL
  • Leiva, Laura; Universidad de Chile. Instituto de Nutrición y Tecnología de los Alimentos. Santiago. CL
  • de la Maza, María Pía; Universidad de Chile. Instituto de Nutrición y Tecnología de los Alimentos. Santiago. CL
  • Barrera, Gladys; Universidad de Chile. Instituto de Nutrición y Tecnología de los Alimentos. Santiago. CL
  • de la Maza, Javier; Hospital Dr. Sótero del Río.
  • Hirsch, Sandra; Universidad de Chile. Instituto de Nutrición y Tecnología de los Alimentos. Santiago. CL
Rev. méd. Chile ; 136(8): 981-988, ago. 2008. ilus, tab
Article Dans Espagnol | LILACS | ID: lil-495796
ABSTRACT

Background:

Antibiotic-associated diarrhea is one of the most common adverse effects of antimicrobials. Any antimicrobial can potentially produce diarrhea but beta-lactamics have a higher risk. Among these, amoxicillin is widely indicated in ambulatory practice. One ofthe alternatives suggested to prevent antibiotic-associated diarrhea, is the use of the probiotic Saccharomyces boulardii.

Aim:

To evalúate whether the concomitant use of Saccharomyces boulardii and amoxicillin can prevent antibiotic associated diarrhea in ambulatory adults with acute infections diseases, without provoking other adverse effects. Material and

Methods:

Eighty six adults (aged 15 to 81 years) with acute infectious diseases, excluding those arising in the gastrointestinal tract, that received a prescription of oral amoxicillin for 5 to 10 days, were included. In a controlled randomized, double blind trial, 41 patients were assigned to receive lyophilized Saccharomyces boulardii (500 mg/day) duríng 12 days, and 45 patients were assigned to placebo for the same period.

Results:

Ten percent of patients (9/86) reported acute diarrhea, 9,8 percent (4/41) in the experimental group and 11.196 (5/45) in the control group (p = 100). No adverse effects were associated to the use of the probiotic.

Conclusions:

Saccharomyces boulardii (500 mg/day) did not prevent diarrhea related to amoxicillin.
Sujets)

Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Saccharomyces / Probiotiques / Diarrhée / Amoxicilline / Antibactériens Type d'étude: Essai clinique contrôlé / Étude observationnelle / Étude pronostique / Facteurs de risque Limites du sujet: Adolescent / Adulte / Adulte très âgé / Aged80 / Femelle / Humains / Mâle langue: Espagnol Texte intégral: Rev. méd. Chile Thème du journal: Médicament Année: 2008 Type: Article Pays d'affiliation: Chili Institution/Pays d'affiliation: Universidad de Chile/CL

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Texte intégral: Disponible Indice: LILAS (Amériques) Sujet Principal: Saccharomyces / Probiotiques / Diarrhée / Amoxicilline / Antibactériens Type d'étude: Essai clinique contrôlé / Étude observationnelle / Étude pronostique / Facteurs de risque Limites du sujet: Adolescent / Adulte / Adulte très âgé / Aged80 / Femelle / Humains / Mâle langue: Espagnol Texte intégral: Rev. méd. Chile Thème du journal: Médicament Année: 2008 Type: Article Pays d'affiliation: Chili Institution/Pays d'affiliation: Universidad de Chile/CL