Asymptomatic Plasmodium spp. infection in Tierralta, Colombia
Mem. Inst. Oswaldo Cruz
;
103(7): 668-673, Nov. 2008. mapas, tab
Article
Dans Anglais
| LILACS
| ID: lil-498375
ABSTRACT
With the aim of determining the prevalence of asymptomatic Plasmodium spp. infection by thick smear and PCR and its association with demographic and epidemiological characteristics in the village of Nuevo Tay, Tierralta, Córdoba, Colombia, a cross-sectional population study was carried out, using random probabilistic sampling. Venous blood samples were taken from 212 people on day 0 for thick smear and PCR. Clinical follow-up and thick smears were carried out on days 14 and 28. The prevalence of Plasmodium spp. infection was 17.9 percent (38/212; 95 percent CI 12.5-23.3 percent) and the prevalence of asymptomatic Plasmodiumspp. infection was 14.6 percent (31/212; 95 percent CI 9.6-19.6 percent). Plasmodium vivax was found more frequently (20/31; 64.5 percent) than Plasmodium falciparum (9/31; 29 percent) and mixed infections (2/31; 6.5 percent). A significantly higher prevalence of asymptomatic infection was found in men (19.30 percent) than in women (9.18 percent) (prevalence ratio 2.10; 95 percent CI 1.01-4.34 percent; p = 0.02). People who developed symptoms had a significantly higher parasitemia on day 0 than those who remained asymptomatic, of 1,881.5 ± 3,759 versus 79 ± 106.9 (p = 0.008). PCR detected 50 percent more infections than the thick smears. The presence of asymptomatic Plasmodium spp. infection highlights the importance of carrying out active searches amongst asymptomatic populations residing in endemic areas.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
ADN des protozoaires
/
Paludisme à Plasmodium vivax
/
Paludisme à Plasmodium falciparum
Type d'étude:
Etude diagnostique
/
Étude observationnelle
/
Étude de prévalence
/
Facteurs de risque
Limites du sujet:
Animaux
/
Femelle
/
Humains
/
Mâle
Pays comme sujet:
Amérique du Sud
/
Colombie
langue:
Anglais
Texte intégral:
Mem. Inst. Oswaldo Cruz
Thème du journal:
Médecine tropicale
/
Parasitologie
Année:
2008
Type:
Article
Pays d'affiliation:
Colombie
Institution/Pays d'affiliation:
Instituto Nacional de Salud/CO
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