Young ovine death during hyperimmunization: crotalic envenomation or copper toxicosis?
J. venom. anim. toxins incl. trop. dis
; 14(4): 738-749, 2008. ilus, tab
Article
de En
| LILACS, VETINDEX
| ID: lil-500141
Bibliothèque responsable:
BR68.1
ABSTRACT
The unfavorable evolution of a young ovine during hyperimmunization process with Crotalus durissus terrificus venom was investigated in order to differentiate its origin between ophidic envenomation and copper toxicosis. Clinical, laboratory, necroscopic and histological exams as well as evaluation and measurement of heavy metals (copper) in the kidneys and in the liver were carried out. Blood counts revealed anemia and serological tests showed high levels of blood urea nitrogen, creatinine, aspartate aminotransferase, creatine phosphokinase, total bilirubin and indirect bilirubin; which indicates liver, kidney and skeletal muscle damages. At necropsy, the animal presented hepatopathy and nephropathy. Histological examination revealed renal and hepatic features that may imply copper intoxication. Copper levels were 237.8 µg/g in the liver and 51.2 µg/g in the kidneys. Although the amount of metal found in both organs was below the level that can cause death, according to the literature, anatomopathological signs were suggestive of copper intoxication. Therefore, the hypothesis of metal toxicosis during the hyperimmunization process became more consistent than the crotalic envenomation one.(AU)
Mots clés
Texte intégral:
1
Indice:
LILACS
Sujet Principal:
Azote uréique sanguin
/
Tests sérologiques
/
Ovis
/
Crotalus cascavella
/
Creatine kinase
/
Mort
Type d'étude:
Diagnostic_studies
Limites du sujet:
Animals
langue:
En
Texte intégral:
J. venom. anim. toxins incl. trop. dis
Thème du journal:
TOXICOLOGIA
Année:
2008
Type:
Article