Nuclear calcium signaling: a cell within a cell
Braz. j. med. biol. res
;
42(1): 17-20, Jan. 2009. ilus
Article
Dans Anglais
| LILACS
| ID: lil-505417
ABSTRACT
Calcium (Ca2+) is a versatile second messenger that regulates a wide range of cellular functions. Although it is not established how a single second messenger coordinates diverse effects within a cell, there is increasing evidence that the spatial patterns of Ca2+ signals may determine their specificity. Ca2+ signaling patterns can vary in different regions of the cell and Ca2+ signals in nuclear and cytoplasmic compartments have been reported to occur independently. No general paradigm has been established yet to explain whether, how, or when Ca2+ signals are initiated within the nucleus or their function. Here we highlight that receptor tyrosine kinases rapidly translocate to the nucleus. Ca2+ signals that are induced by growth factors result from phosphatidylinositol 4,5-bisphosphate hydrolysis and inositol 1,4,5-trisphosphate formation within the nucleus rather than within the cytoplasm. This novel signaling mechanism may be responsible for growth factor effects on cell proliferation.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Noyau de la cellule
/
Récepteurs à activité tyrosine kinase
/
Signalisation calcique
/
Prolifération cellulaire
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
2009
Type:
Article
/
Congrès et conférence
/
descriptif de projet
Pays d'affiliation:
Brésil
/
États-Unis d'Amérique
Institution/Pays d'affiliation:
Universidade Federal de Minas Gerais/BR
/
Universidade de Brasília/BR
/
Yale University School of Medicine/US
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