Ca2+ signaling in pancreatic acinar cells: physiology and pathophysiology
Braz. j. med. biol. res
;
42(1): 9-16, Jan. 2009. ilus
Article
Dans Anglais
| LILACS
| ID: lil-505429
ABSTRACT
The pancreatic acinar cell is a classical model for studies of secretion and signal transduction mechanisms. Because of the extensive endoplasmic reticulum and the large granular compartment, it has been possible - by direct measurements - to obtain considerable insights into intracellular Ca2+ handling under both normal and pathological conditions. Recent studies have also revealed important characteristics of stimulus-secretion coupling mechanisms in isolated human pancreatic acinar cells. The acinar cells are potentially dangerous because of the high intra-granular concentration of proteases, which become inappropriately activated in the human disease acute pancreatitis. This disease is due to toxic Ca2+ signals generated by excessive liberation of Ca2+ from both the endoplasmic reticulum and the secretory granules.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Pancréatite
/
Signalisation calcique
/
Pancréas exocrine
Type d'étude:
Etude d'étiologie
/
Étude pronostique
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
2009
Type:
Article
/
Congrès et conférence
Pays d'affiliation:
Royaume-Uni
Institution/Pays d'affiliation:
University of Liverpool/GB
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