Molecular genotyping and epidemiology of Mycobacterium tuberculosis isolates obtained from inmates of correctional institutions of Campinas, Southeast Brazil
Braz. j. infect. dis
;
12(6): 487-493, Dec. 2008. ilus, tab
Article
Dans Anglais
| LILACS
| ID: lil-507448
ABSTRACT
The objective of this study was to investigate the possible transmission of tuberculosis among 39 inmates with positive Mycobacterium tuberculosis smears in four correctional institutions located in Campinas City, SP, Brazil over a 19-month period. Fifty-one M. tuberculosis isolates from these inmates were characterized according to the number of IS6110 insertion elements present in their genomic DNA. The number of insertion elements in M. tuberculosis isolates varied from two to twelve. The dendrogram of similarity resulted in the grouping the isolates in six main clusters. These results, associated to epidemiological data, suggested the transmission of tuberculosis among inmates of the same and different institutions inmates. Univariate analysis of epidemiological data (total delay for beginning of treatment, previous treatment, and HIV status) and clustering occurrence showed that only "previous treatment" (OR = 7.65, p = 0.032) was associated with the possible transmission of tuberculosis in the studied prisons.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Prisons
/
Tuberculose pulmonaire
/
ADN bactérien
/
Mycobacterium tuberculosis
Type d'étude:
Étude observationnelle
/
Facteurs de risque
/
Étude de dépistage
Limites du sujet:
Adulte
/
Humains
/
Mâle
Pays comme sujet:
Amérique du Sud
/
Brésil
langue:
Anglais
Texte intégral:
Braz. j. infect. dis
Thème du journal:
Maladies transmissibles
Année:
2008
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Adolfo Lutz Institute of Campinas/BR
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