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Use of drugs that act on the cytochrome P450 system in the elderly
Cabrera, Marcos A. S; Dip, Renata M; Furlan, Maira O; Rodrigues, Sara L.
  • Cabrera, Marcos A. S; Universidade Estadual de Londrina. Londrina. BR
  • Dip, Renata M; Universidade Estadual de Londrina. Londrina. BR
  • Furlan, Maira O; Universidade Estadual de Londrina. Londrina. BR
  • Rodrigues, Sara L; Universidade Estadual de Londrina. Londrina. BR
Clinics ; 64(4): 273-278, 2009. tab
Article Dans Anglais | LILACS | ID: lil-511926
ABSTRACT

OBJECTIVES:

The objective of this study was to analyze medications that act on the cytochrome P450 (CYP450) enzymatic system and are used daily by non-institutionalized elderly individuals.

METHODS:

A cross-sectional population-based study of elderly individuals (> 60 years old) was conducted. All continuously used medications with hepatic metabolism via CYP450 that are classified as substrates, inducers or inhibitors were considered. For the analysis, elderly individuals were stratified according to age groups, and hepatic metabolism activity due to daily alcohol consumption and smoking were considered.

RESULTS:

Elderly individuals (396 in total 222 women and 174 men) between 60 and 95 years of age (mean 72.1) were assessed. Use of drugs that act on CYP450 was identified in 61.6 percent of the subjects. Drug use was observed among 16.2 percent of the

subjects:

three drugs among 9.8 percent and four or more among 6.3 percent of the subjects. The metabolic activities of the drugs used were classified as substrates (58.8 percent), inhibitors (14.9 percent), and inducers (4.3 percent). The main drugs used were beta-blockers and statins (as substrates), proton pump inhibitors and fluoxetine (as inhibitors), and prednisone and carbamazepine (as inducers).

CONCLUSIONS:

The results demonstrate that the elderly use high levels of medications that act on CYP450, thereby increasing the risk of drug interactions in a group that is already vulnerable to adverse drug effects.
Sujets)

Texte intégral: Disponible Indice: LILAS (Amériques) Type d'étude: Étude observationnelle / Étude de prévalence / Facteurs de risque Limites du sujet: Adulte très âgé / Aged80 / Femelle / Humains / Mâle langue: Anglais Texte intégral: Clinics Thème du journal: Médicament Année: 2009 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade Estadual de Londrina/BR

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Texte intégral: Disponible Indice: LILAS (Amériques) Type d'étude: Étude observationnelle / Étude de prévalence / Facteurs de risque Limites du sujet: Adulte très âgé / Aged80 / Femelle / Humains / Mâle langue: Anglais Texte intégral: Clinics Thème du journal: Médicament Année: 2009 Type: Article Pays d'affiliation: Brésil Institution/Pays d'affiliation: Universidade Estadual de Londrina/BR